http://answers.yahoo.com/question/index?qid=20060823000131AA3qCGG
Now I can tell you some vets are not very familiar treating the giant breeds. When I took my Mastiff in to another vet after he wasn't getting any better under the care of his usual vet, the new vet wanted to remove his toe nail without giving him anything to relax or calm him. I looked at the vet and said, "this is a 200lb dog and you going to remove his toe nail just like that?" She then thought better of it and put him under.